SISTA Colloquium Series
|Date||Monday, November 7, 2011|
|Details||Light refreshments in Gould-Simpson 9th floor atrium before talk.|
|Speaker||Jennifer Barton, Professor & Head, Dept. of Biomedical Engineering|
|School/Dept.||Assistant Director, Bio5 Institute|
|Affiliation||University of Arizona|
Analysis of Optical Coherence Tomography and Multi Photon Microscopy Images
Optical imaging tools have the potential to detect the earliest stages of cancer, at a time when the disease is highly curable. We are developing two optical tools- optical coherence tomography (OCT) and multi photon microscopy (MPM)- for imaging mouse models of colon and ovarian cancer. OCT relies on reflected light to create cross sectional images of tissue microstructure (3-10 µm resolution). MPM uses non-linear effects of high intensity light to create sub cellular images (<1 µm resolution).
Both modalities could benefit from automated methods of analysis and classification. OCT images are highly noisy and we have had some limited success with texture analysis methods. MPM images are more amenable to analysis. We have performed initial frequency and texture-based analysis on MPM images of mouse ovary with promising results.