The University of Arizona

SISTA Colloquium Details

Monday, April 18, 2011

12:00 – 12:50 p.m.

Gould-Simpson Building, Room 906

Light refreshments in 9th floor atrium area - 11:50 a.m.



Andrew Capaldi, Assistant Professor
Department of Molecular and Cellular Biology

University of Arizona



Network Level Dissection of Eukaryotic Cell Signaling Circuits



Cells utilize complex signaling circuitry to process information and make decisions.  I will discuss a novel approach we are taking to reverse-engineer these signaling circuits by examining global gene expression patterns in cells with different signaling pathways mutated.  I will then describe the results of a new study we are carrying out using this approach to look at the circuitry that controls cell growth in euykaryotes.  Our data to date reveal several novel aspects of signal processing in cells, and I will compare these newly discovered design features to those found in electronic circuits.