SISTA Colloquium Details
Monday, February 28, 2011
12:00 – 12:50 p.m.
Gould-Simpson Building, Room 906Light refreshments in 9th floor atrium area - 11:50 a.m.
Andrew C. Hausrath, Assistant Professor
Department of Chemistry and Biochemistry
The University of Arizona
Title: Filamentary Density Distributions and their Applications In Microscopy
Abstract: Structural biologists can create atomic coordinate models of macromolecules using high-resolution techniques, and many biological properties can be understood using such models. However, most biological processes are carried out not by individual molecules acting in isolation, but by higher-order assemblies, which are challenging for current high-resolution methods. Further, such higher-order biological assemblies are often heterogeneous in size, shape, and composition. Both because of the technical limitations of current experimental methodology, and because of the difficulty in applying the traditional coordinate models to such complexes, we are pursuing development of an alternative description of biological structures based on filament-like spatial density distributions. The talk will emphasize some computational challenges associated with their use in applications from microscopy.