The University of Arizona

SISTA Colloquium Details


Monday, February 28, 2011

12:00 – 12:50 p.m.

Gould-Simpson Building, Room 906

Light refreshments in 9th floor atrium area - 11:50 a.m.


Andrew C. Hausrath, Assistant Professor

Department of Chemistry and Biochemistry
The University of Arizona

Title: Filamentary Density Distributions and their Applications In Microscopy

Abstract: Structural biologists can create atomic coordinate models of macromolecules using high-resolution techniques, and many biological properties can be understood using such models. However, most biological processes are carried out not by individual molecules acting in isolation, but by higher-order assemblies,  which are challenging for current high-resolution methods.  Further, such higher-order biological assemblies  are often heterogeneous in size, shape, and composition.  Both because of the technical limitations of current experimental methodology, and because of the difficulty in applying the traditional coordinate models to such complexes,  we are pursuing development of an alternative description of biological structures based on filament-like spatial density distributions. The talk will emphasize some computational challenges associated with their use in applications from microscopy.