The University of Arizona

SISTA Colloquium Details

Date: Monday, November 29, 2010

Time: 12:00 p.m.

Location: Gould-Simpson Bldg., Room 906
Light refreshments: 9th floor atrium area - 11:50 a.m.

Speaker:  Felicia Goodrum, Assistant Professor
Department of Immunobiology

The University of Arizona

Title: Virus-Host Interactions in Viral Coexistence


Abstract: Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus infecting up to 99% of the world's population. Following primary infection, the virus coexists in individuals indefinitely by way of a latent infection. While the mechanisms underlying coexistence and latency are poorly understood, as they involve coordinated interactions between multiple viral and cellular factors, we have identified the first determinant of HCMV latency. Our laboratory is also interested in the role of chromatinization of the viral genome in dictating the outcome of HCMV infection, ultimately to identify the host-virus interactions critical to latency and pathogenesis.